Keep an eye on Intently (1)pentobarbital will decrease the level or result of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to a minimize in fentanyl plasma concentrations, lack of efficacy or, maybe, progress of a withdrawal syndro… Read More